Mixture Toxicity

January SFT Seminar 2022

Topic: Mixture toxicity: from research to risk assessment

Date: Friday, the 21st of January between 14:00 - 16:00 (CEST)

Location: zoom (please see the bottom of the page for the link)

Structure:  Three speakers with 30 min presentations each followed by some immediate short questions, and a 30 min panel discussion at the end of all the presentations.

Description: As was discussed in the previous SFT seminar, the new EU Strategy for Sustainability placed an emphasis on the group-wise regulation and accounting for mixtures. In this seminar experts in the field will dive into their research on the development of new methods to study and predict mixture toxicity, development of new methods to identify relevant chemical mixtures, improving risk assessment and more.

This is a free seminar for all, engaging a broad science and policy communication and open discussion.



Prof. Dr. Rolf Altenburger

Head of the Department Bioanalytical Ecotoxicology, RWTH Aachen University, Germany

 Title: How well can we predict combined effects?

Rolf Altenburger, Biologist. Academic stations Universities of Marburg, St.Andrews, Freiburg, Bremen. Research positions at University Bremen, UFZ-Helmholtz Centre for Environmental Research Leipzig, RWTH Aachen University. Research Fellowships to Roswell Park Cancer Institute, Buffalo, USA and University of Brisbane, Australia). Current position Head of research unit “Chemicals in the Environment” at UFZ Leipzig and Prof. for Bioanalytical Ecotoxicology at the RWTH Aachen.

Research Interests:

  • Mixture toxicity analysis for identification of risk drivers under complex environmental exposure
  • Mechanism-based prediction of combined effects based on experimental and theoretical (eco)toxicological research using organism model systems and process-based concepts to provide novel assessment methods for detection, monitoring, prediction of adverse contaminant effects.


Prof. Dr. Chris Gennings

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, USA

Title: Environmental Mixtures and Nutrition: Metrics for Change

Dr. Chris Gennings is professor and Director of the Biostatistics Division within the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai. Her research interests focus on design and analysis methodologies for studies of complex mixtures, with recent focus on Weighted Quantile Sum (WQS) regression, methods for risk assessment of environmental mixtures, development of a nutrition index called My Nutrition Index with a web-based nutrition app, and using g-computation methods with indices such as the My Nutrition Index and a WQS index of environmental exposures to address the counterfactual question of “what if” exposures were reduced and dietary nutrition was improved.


Prof. Dr. Christina Rudén

Department of Environmental Science, Stockholm University, Sweden

Title: Managing mixture risk – policy needs and ongoing developments

Christina Rudén is Professor in Regulatory toxicology and ecotoxicology at the Department of environmental science, Stockholm University, Sweden.

Her research focuses on analyzing and evaluating the foundations and workings of EU chemicals legislation, and how science is used for regulatory decision-making. The overall purpose is to contribute to developing scientifically well-motivated improvements of the legal system and its practices. Rudén has published some 75 articles about regulatory toxicology in international peer reviewed journals.

She is a member of the Swedish Chemicals Agency’s Supervisory Council. She is representing SU as an observer in the CARACAL (Competent Authorities for REACH and CLP) and she is a member of the European Commission’s High-Level Roundtable Expert group on the implementation of the Chemical Strategy for Sustainbility. She has been a member of ECHA’s Management Board (nominated by the European Parliament) and she has served as an expert for the Swedish Government on the issue of pharmaceuticals in the environment, and as a special inquirer for mixture risk assessment and grouping of chemicals.

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